Endocrine Abstracts

Introduction: Pregnancy is rare in patients with Cushing Disease (CD) owing to ovulatory dysfunction. When surgery is not curative, medical treatment is usually considered. Ketoconazole and mitotane, commonly used medical therapies, have questionable teratogenicity and are not often options in pregnancy. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease. Observational studies suggested that low dose cabergoline treatment at the time o...

Introduction: We wanted to analyse the descriptive variables of a series of 1567 thyroidectomy patients between 2010 and 2013 and its association with malignancy in our series.Material and methods: Retrospective, multicentre study done by review of the medical records of 1567 patients who became thyroidectomy between 2010 and 2013 in eight sanitary areas. This is an analysis of clinical and demographic variables.Results: The percen...

Introduction: We wanted to analyse the pathology results of thyroidectomies performed in the hospitals of Castilla La Mancha (Spain) between the years 2010 and 2013, inclusive.Material and methods: A retrospective, multicentre, descriptive study of the histopathological results of the 1567 thyroidectomies performed in the hospitals of the eight health districts in our region between the years 2010 and 2013.Results: The histopatholo...

Background: Recent reports suggest that female sex could be an indicator of better response to liraglutide in patients included in clinical trials.Aim: To compare efficacy of liraglutide in women and men with type 2 diabetes mellitus (T2DM), in real clinical practice.Patients and methods: Our study included 116 patients with T2DM and obesity (BMI >30) attending outpatient clinic, which initiated with liraglutide (0.6 mg/daily f...

Introduction: Generously supported by IPSEN)-->Prolactin (PRL) -secreting adenomas are about 40% of all pituitary adenomas. Their clinical symptoms are mainly related to development of secondary hypogonadism and/or tumor mass effects. Dopamine agonists (DA) are first-line drugs for prolactinoma patients due to their effectiveness in normalizing PRL levels and shrinking tumour mass. Surgery is an option for DA failure or tumour mass e...

The recommended nutrient intake (RNI) for iodine during pregnancy has been re-evaluated in 2005 by an international expert committee under the auspices of the World Health Organization (WHO). The consensus reached was that the RNI for iodine during pregnancy should range between 200 and 300 μ/d with an average of 250 μ/d.To asses the adequacy of the iodine intake during pregnancy in a population, urinary iodine concentration (UIC) should be mea...

IntroductionPost parathyroidectomy cure in primary hyperparathyroidism (PHPT) is defined as normocalcemia six months after surgery. The frequency of persistent or recurrent post-surgical disease according to lengthy follow-up studies varies between 1% and 14%.ObjectiveTo determine if there is a subset of patients with cure criteria 6–12 months after parathyroidectomy that would not require long-term foll...

IntroductionThe association of autoimmune, nodular or neoplastic thyroid disease and primary hyperparathyroidism (PHPT) has been reported in 17 to 84% of cases. In the surgical treatment of PHPT, simultaneous thyroidectomy may be necessary to optimize surgical access and / or when there is abnormal thyroid pathology. On the other hand, an incomplete diagnosis in the previous study of PHPT increases the risk of not removing clinically significant thyroid ...

Introduction and objective: Prophylactic central lymph node dissection (CLND) in patients with suspected papillary thyroid cancer (PTC) without evident lymph node metastasis (LNM), remains debatable. We propose to evaluate whether BRAF V600E mutation presence, could help to identify patients at risk for LMN.Methods: Retrospective study of patients with diagnosis of PTC, who underwent total thyroidectomy during 2002 and 2013 (n: 256) in our hospi...